It became clear that to make a genuine difference in the way science was being learned, there would have to be some major capital expenditures.

However, though it may not be; as great as has sometimes been maintained there is a genuine difference.

There may be genuine differences of opinion about the desirability of continuing community care for that person.

There can be genuine differences in quality between photographs made by an artist at various stages of life.

No one begrudges someone who makes a genuine difference, the star performer, a hefty pay package.

I realize in some cases that there are genuine philosophical differences.

This leads to genuine differences in the computational properties.

Discount rates finally start to make a genuine difference in Russia.

Still, he added, "the hurdles to our relationship are large because of distance, bias and also genuine differences in how we approach issues."

I'm not saying that's a genuine difference between British and American politicians.