Rather than being angry at this, Alex Hunter hoped that this kind of pressure could lead to a genuine breakthrough in the case.

The industry is counting on research into genetics and the basic mechanisms of cellular behavior to produce genuine breakthroughs in treatment for diseases like diabetes.

Nevertheless, many scientists see chaperones as a genuine breakthrough in the otherwise discouraging discipline.

By rights the Admiral should have been pleased at the genuine breakthrough in the final negotiations with the Rihannsu.

In the same climate, a whole film that concerns itself with moral issues amounts to a genuine breakthrough.

By late 1980 Julian began to feel that there was a genuine breakthrough in his relationship with his father.

Perhaps the Commission could give a clear signal here, too, in order to help digital television to make a genuine breakthrough in Europe.

Ladies and gentlemen, a genuine breakthrough in the transport of animals will only come about when long-distance transports are fully abolished.

I think that Slovakia marks a genuine breakthrough in European history!

What could have been a genuine breakthrough then turned into another downward spiral.