When the first generic copy of a conventional drug becomes available, it may cost 15 percent less than the brand-name product.

One proposal debated today would expand access to low-cost generic copies of brand-name medicines.

When patent protection expires after 20 years, generic copies rush into the market at even lower prices.

The government officials were thought to be particularly troubled by the big companies' pledge not to issue their own generic to compete with the Apotex copy.

In 1992, the agency approved 229 new generic copies, including 31 types not previously available.

The fund must also be willing to pay for generic copies of drugs patented in wealthy countries, so as to help the most people.

A Senate committee last week approved a bill to expand access to low-cost generic copies of brand-name medicines.

Manufacturers are shifting to over-the-counter sales because of competition from generic copies.

Pfizer has been under pressure for several years from the makers of generic copies of Diflucan.

Both make vaccines and lower-priced generic copies of brand-name drugs.