A solution to this problem would be to generate human antibodies directly from humans.

Janda demonstrated that one could manipulate the immune system to generate antibodies against cocaine.

As anyone who has ever done any immunology will know, it is pretty easy to generate antibodies that cross-react non-specifically.

The immune system can generate antibodies that will selectively bind with almost any molecule.

But in some cases, particularly in the case of biological warfare agents, it is unethical to expose people to generate antibodies.

The immune system does not efficiently generate antibodies against them and infections often persist at extremely low levels, making other forms of detection technically challenging.

In the past few years, an increasing number of research groups in academia and industry have employed similar methodologies to generate human monoclonal antibodies.

Early in his career Schultz showed that the natural molecular diversity of the immune system could be directed to generate catalytic antibodies.

MorphoSys generates human antibodies that contain 100% human proteins.

A researcher can generate several primary antibodies that recognize various antigens (have different variable regions), but all share the same constant region.