And when they unearthed promising candidate genes, they checked to see if the gene differed at all between a family member who had the cancer, and one without the tumor.
The genes differ.
These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.
This gene differs from defensin, alpha 1 by only one amino acid.
The complete gene of mouse CERK differed slightly, containing a 1593bp open reading frame.
One is to look at how the genes of centenarians differ from those of the rest of the population.
However, fish and human genes differ significantly in the size of the transcription unit, the number of exons, and the splicing patterns of the exons.
Cpn 10/10.1 and Cpn 1054 are especially interesting, as the two genes differ by only a few nucleotides over a 2,400 base pair coding sequence.
This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor.
This gene (UBE3A, part of the ubiquitin pathway) is present on both the maternal and paternal chromosomes, but differs in the pattern of methylation (imprinting).