This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2.

A fusion gene is a hybrid gene formed from two previously separate genes.

Most fusion genes are found from hematological cancers, sarcomas, and prostate cancer.

Oncogenic fusion genes may lead to a gene product with a new or different function from the two fusion partners.

Biologists may also deliberately create fusion genes for research purposes.

These mutations are distinct from fusion genes which merge whole gene sequences into a single reading frame and often retain their original functions.

Caused by different structural modifications in the genome, fusion genes have gained attention because of their relationship with cancer.

Translation of this fusion gene results in a single polypeptide with functional properties derived from each of the original proteins.

Many important cancer-promoting oncogenes are fusion genes produced in this way.

The fusion genes were injected into embryos and expression examined by fluorescent microscopy in live embryos.