There were no significant clinical differences between RP and control cases except for more frequent extraintestinal manifestations (38% v 5%) and male preponderance (79% v 43%) in RP.

Pericarditis is a frequent cardiac manifestation.

Venous sinus thrombosis is the most frequent vascular manifestation in NBD followed by cortical cerebral veins thrombosis.

The most frequent clinical manifestations are fever, weight loss, anorexia, abdominal pain, debilitating diarrhea, and malaise.

A frequent manifestation is Candidal intertrigo.

Excessive sweating, however, is also a frequent manifestation of social phobia, which is more than 10 times as common.

Rigidity may be associated with joint pain; such pain being a frequent initial manifestation of the disease.

Diabetes insipidus (DI) is the most frequent endocrine manifestation in LCH.

The frequent manifestation of a melancholy figure at Covent Garden Underground Station has earned it the unwanted title of the most haunted station on the London Transport system.

Nocturnal cough is a frequent manifestation of this process and a frequently overlooked symptom of HF.