Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease.
However, familial cases have also been reported.
Pleural fibrosis can be idiopathic, and isolated familial cases have been reported.
These cases seem to have the same causes as the familial cases and represent de novo mutations.
We included genetic counselling alone, for familial cases when no prenatal diagnosis is available, among primary preventive approaches.
Malignant serous tumors occur later in life on average, although somewhat earlier in familial cases.
There are some familial cases in which these tumors are multicentric rather than solitary.
In 1966, three familial cases were added, a mother, her son and daughter.
Although most cases of Sotos syndrome occur sporadically, familial cases have also been reported.
However, some familial cases have been reported.