Patients who have had an initial complete response to first-line chemotherapy and those without extensive disease have the most favorable outcomes.

Systemic therapy should be chosen based on the eye with more extensive disease.

Each year, about 350,000 Americans who had no symptoms die suddenly and are found at autopsy to have had extensive coronary disease.

Oral aminosalicylates are used to treat mild to moderate extensive disease (pancolitis).

Antibiotics are ineffective in more extensive disease and surgery is always required.

Water supplies are untreated and there is no treatment of human waste, leading to extensive disease.

Treatment of extensive regional disease has thus far not had well-documented success by either radiation or systemic chemotherapy.

Patients with extensive regional disease should be considered for clinical trials.

Longer courses of treatment might be required for extensive disease or poor response after 6 weeks.

This is often because of extensive disease or poor liver function.