During the early 20th century, the region became relatively poor and economically isolated.

With the change of commercial routes to Anápolis, the city became economically isolated.

It wasn't in the nature of spacefaring cultures to be economically isolated.

Some consider this region very economically isolated, mostly due to its lack of interstate highways.

Although until the 1960s, many indigenous communities were considered by scholars to be autonomous and economically isolated, this was never the case.

Any faction that doesn't turn over war criminals should be diplomatically and economically isolated.

But clearly there is a connection between schools that are racially and economically isolated and poor student performance.

This left Tlaxcala economically isolated, leaving it without goods such as cotton and salt.

Although most small towns and villages had not suffered as much damage, the destruction of transportation left them economically isolated.

Because of its geographic position and distance from the railroad and the main highways, it became economically isolated.