The lower dose (1 mg/kg)did not reduce heart rate.

However, the higher dose reduced HR byapproximately 15% for 8 hours.

The higher dose of carvedilol significantly reduced heart rate andblood pressure for up to eight hours.

But it was not clear to what extent the new doses would reduce the problem.

Moderate to high doses may reduce cardiovascular disease risk but are of questionable clinical significance.

Higher doses of insulin reduce the blood sugar level more than lower doses.

Time-released formulations and lower doses reduce the risk of side effects.

High doses of fish oil might also reduce the immune system's activity, reducing the body's ability to fight infection.

But women have another vitamin C problem to worry about: large doses of it may reduce fertility.

But the high dose did not reduce overall deaths, because patients on that dose were more likely to die from cancer and other factors.