A dose of 10-15 grams of sodium chlorate can be lethal.
At the proposed starting dose of 5 grams, the drug was found to be generally well tolerated with side effects that were mild to moderate.
Class II materials are estimated to be fatal to an adult human at a dose of 5 to 30 grams.
A loading dose of 9 grams per day for 6 days has also been used.
When doses of over 3 grams per day of niacin are taken, more serious side effects can happen.
Single doses of 10-30 grams of zinc can be fatal.
Following an oral dose of 2 grams peak serum levels are reached after approximately 6 hours.
"We used a dose of 30 grams in our study, and are about to begin a new trial using 60 grams."
Threonine seems to be safe when doses of 2 grams to 4 grams daily are taken for up to 12 months.
Without intervention, about half the people who swallowed a single dose of 12 to 15 grams could die.