After peaking at week 1, the morphine equivalent daily dose decreased significantly at weeks 8 and 12, before rising again at week 24.

The warning stated that "the extra dose of bimatoprost may decrease the prescription drug's effectiveness.

Single doses can decrease blood sugar levels by 17% to 46% in some people.

High doses of chemotherapy or radiation therapy decrease the number of white blood cells, which fight infection.

Of course, higher doses of tranquilizers can also decrease a horse's performance.

A complicating issue may be a narrow therapeutic window; lower doses decrease pain but higher doses have the opposite effect.

The dose then decreases rapidly with depth, sparing underlying tissue.

This is called a J-shape dose-response, low doses decrease the risk, and only higher doses increase the risk.

Over five days of treatment the dose would decrease from a high of maybe thirty milligrams a day down to zero.

Lower doses of craniospinal radiation therapy may decrease the incidence of hypothalamic dysfunction, but this has not yet been proven.