The religious difference - he is Roman Catholic, she is Jewish - posed no problem.
Cultural differences, while perhaps seeming unimportant on the surface, can pose serious problems in international mergers of auto makers.
That visceral difference in viewpoint may pose the most elusive but enduring barrier to improvements, some Asian scientists say.
The enormous differences between the regions pose a serious structural problem in the Angolan economy.
The difference in types of partners posed many problems, among which was that of responsibility.
The difference in texture between the new and old turf could also mean a difference in traction, and might pose a safety hazard for players.
These morphological differences pose no health risk, and are simply a difference in form.
Such differences between operatic and balletic time pose choreographic challenges.
The differences between the national systems pose serious problems for consumers, who are purchasing more and more goods abroad.
And this difference poses a question about how each great power absorbs defeat, how it learns and how its experience affects its policy.