Despite the building's historical significance, the college contends that it is beyond repair.

Despite its architectural significance, the building is still one among the least studied monuments of Istanbul.

Despite its historical significance, demolition of the estate has been proposed for sometime and is scheduled to begin in 2013.

Yet despite its significance, the 50's are a relatively unknown decade, little discussed, and even less studied.

Despite the event's significance, it receives very little historical attention.

Despite its architectural significance, the building has never undergone a systematic study.

Despite their historical and cultural significance, many of these publications were forced to close following pressure from local authorities.

Despite its tremendous significance there was not much to it really.

Despite its biological significance, the reaction mechanism of fumarase is not completely understood.

These reservations can therefore be dealt with, despite their significance.