However, the potential toxicity of prolonged cytokine expression has not been established, and in many commercially important animal species, cytokine genes still need to be identified and isolated.

CpG-S sequences induce polyclonal B-cell activation and the upregulation of cytokine expression and secretion.

It has also been reported that UV radiation would lead to local and systemic immunosuppression, due to DNA damage and altered cytokine expression.

In vivo anti-tumor activity of thalidomide is believed to be due to the potent anti-angiogenic effect and also through changes in cytokine expression.

Baird et al have demonstrated cytokine expression in tissue from Dupuytren patients, and certain inflammatory cells are known to be potential sources of these intercellular signalling molecules.

IDO is induced (produced on demand) by activation of inflammatory processes involving cytokine expression by white blood cells.

However, the frequency of cytokine expression by RA synovial CD4 +T cells has not been analyzed accurately.

The induction of the AP1 transcription factor, and through this mechanism stimulation of cytokine expression, has also been demonstrated from integrin-ligand interaction.

A recent study shows that (-)schisandrin B produces anti-allergic effect and inhibited inflammatory cytokine expression in mouse bone-marrow-derived mast cells.