She bore him sixteen children over the course of their marriage.

During the course of their marriage, the couple had four sons.

Over the course of their marriage, they had seven children.

She had several miscarriages over the course of their marriage.

How many times had she said those same words to him in the course of their marriage?

Also, there was no mortgage: her parents had paid it off during the course of their marriage.

Several times during the course of their marriage, she had almost revealed her secrets to him.

Over the course of their marriage, the couple had five children, one of whom died in childhood.

The couple had thirteen children over the course of their marriage.

Whatever happens in the course of your marriage, I imagine you will learn a great deal about pleasure.