These discoveries have led to considerable private anguish and the breakup of many friendships.

"This cuts to our core values," he told me with considerable anguish.

It gave him considerable anguish and invited much soul-searching.

For some the strain of living together without legal ties leads to considerable anguish.

Ridiculous, yes, but at the time all this caused considerable anguish in the women's movement.

After considerable anguish, liberal Democrats who oppose any tax cut at all decided to support the amendment as the lesser of evils.

This image was arrived at only after considerable anguish, like deciding what to wear on a first date, only with a different goal in mind.

Rushworth's remains have never been found, causing considerable anguish to her family, the court heard.

There was, however, considerable anguish over one issue.

However, his failing eyesight had been a source of considerable anguish to him.