He wended his way through the Blue Jay lineup unscathed for 17 consecutive outs.
Lopez left the game after retiring Kenny Lofton, and the Orioles' relievers posted five consecutive outs.
His 22 consecutive outs included seven of his season-high eight strikeouts.
Show walked Jose Oquendo with two outs in the ninth to break a streak of 17 consecutive outs.
The total would reach 17 consecutive outs before the Mets managed a meaningless run in the ninth.
Getting the record for consecutive outs, the left-hander said, "would've been nice, but it didn't happen."
He recorded nine consecutive outs through three innings before giving up a solo home run to Joey Votto in the bottom of the 8th.
Vazquez was the Montreal pitcher whose teammates gave him no help in making 27 consecutive outs against Cone on July 18.
Some outs for a hand require drawing an out on both the turn and the river-making two consecutive outs is called a runner-runner.
After three consecutive outs that further diminished his already diminutive average, the rookie second baseman singled in the seventh with a man on second.