Trying to defeat that, researchers try ever more complicated regimens.

For many others, however, the disease is aggressive and requires complicated medical regimens with specialized medications.

Doctors wouldn't risk wasting scarce organs on someone who might not be able to follow the complicated regimen of post-transplant drugs.

This is especially important for patients with complicated regimens (like multidrug therapy for AIDS) and for those with memory problems.

Mr. Mbeki has also emphasized the difficulties that many Africans experience in taking the complicated regimens of multiple drugs every day.

Nonetheless, treatment failures occur as a result of the development of resistance and/or noncompliance with complicated and often toxic regimens.

Diabetes and the complicated regimen required to control it have not derailed his career.

Even in the West, where we have an array of social agencies to help, patients do not always comply with complicated regimens of H.I.V. treatment.

Since the homeless are generally unable to carry out complicated regimens, physicians must devise treatments that are practical on the street, Dr. Woods said.

Some researchers have also found that families already under great stress are less able to cope with the complicated daily regimen that asthma demands.