Stephen Novick, co-creative director of the agency, said the commercial is intended to appeal to more self-confident consumers.
Simpson is the co-creative director of the line, which was released in the winter of 2011.
In 2001, he was named as co-creative director of Eziba, a leading retailer of global craft.
His wife, Amanda Robson, was also hired as co-creative director.
The co-creative directors will report to him.
Michael Hampton, who had also been executive vice president and co-creative director, will retire, serving the agency as a consultant.
Perhaps the most significant change at Ayer is the addition of Ms. Read as a co-creative director.
Don Slater, executive vice president and co-creative director, said he would resign from the agency, which he helped found 14 years ago.
Two executives will assume her duties at the New York office, each with the title of vice chairman and co-creative director.
Joseph Genova, 47, the agency's president and co-creative director, remained independent.