There is a broad range of clinical severity.

There appears to be substantial variability in the clinical severity for different genetic abnormalities at that same MTM1 gene.

Further, published cases show significant differences in clinical severity among relatives with the same genetic abnormality at the MTM1 gene.

Because we had an interest in comparing methodologies, a second, simpler scoring system for clinical severity, as described by Costa et al, was also used.

Up to the date of the study, clinical severity was similar to 1957 and less than 1918 flu pandemic.

However, the clinical severity of the outbreak and how the virus will evolve cannot yet be predicted.

In general, clinical severity mirrors the degree of enzyme deficiency.

The presence or absence of the skin lesions is not helpful, however, in predicting clinical severity in Hunter syndrome.

In some people with Hunter syndrome, analysis of the I2S gene can determine clinical severity.

Even when looking only at this form of elliptocytosis, there is a high degree of variability in the clinical severity of its subtypes.