Any current available local anesthetic hardly produces clinical effects 12 hours after a single injection.

The clinical effects of joint manipulation have been shown to include:

The administration of ebastine with food does not cause a modification in its clinical effect.

Lesions of the complex have no known clinical effects.

But one problem with this theory is that antidepressants increase the levels of these neurotransmitters within days, yet their clinical effects take several weeks.

For this reason, the dose must be carefully adjusted to achieve the desired clinical effect.

This strategy is used to build tolerance to adverse events or to reach a desired clinical effect.

Additional studies are necessary to correlate these concentrations with clinical effects.

Off-target binding to related molecules could have significant clinical effects.

Further research is required to determine if diet changes may have a clinical effect on the course of the disease.