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The ads, which begin appearing in trade publications today, challenge an assumption that the magazine's audience consists predominantly older women.
The new findings challenge an assumption that experts had relied on in attempting to predict earthquakes in faults like the San Andreas.
"Second Chances" is most provocative, however, because it challenges an assumption so comforting to divorced couples - that what's good for the parents will instantly be good for the children.
In 2002, the RAND Drug Policy Research Center released a paper on one of their studies stating that it "casts doubt on claims that marijuana acts as a "gateway" to the use of cocaine and heroin, challenging an assumption that has guided U.S. drug policies since the 1950s."