The central domain is located in the center of the growth cone nearest to the axon.

The transitional domain is the region located in the thin band between the central and peripheral domains.

Homology models have been built for the central and C-terminal domains.

The central domain of Versican is decorated with glycosaminoglycans.

The central hydrophobic domain is proposed to be made up of beta-strand structure and to interact with the lipids.

The central domain is the Hsp90 chaperone (heat shock protein 90) binding domain.

The precise function of the central domain has not been fully elucidated, but it is thought to be important in aiding catalysis.

The Mdm2 protein also contains a central acidic domain (residues 230-300).

Additionally, phosphorylation at certain residues within the central acidic domain of Mdm2 may stimulate its ability to target p53 for degradation.

Each monomer consists of a central domain and a C-terminal alpha helix.