Tumors in Meckel's diverticulum may cause bleeding, acute abdominal pain, gastrointestinal obstruction, perforation or intussusception.

Flying with a severe cold can also cause perforation due to changes in air pressure and blocked eustachian tubes resulting from the cold.

Sigmoidoscopy can also cause perforation and bleeding, although this is rare.

More rarely, abortion causes perforation of the uterus, hemorrhage or infection.

If the coffee is inserted too quickly or is too hot, it could cause internal burning or rectal perforation.

Esophageal or colonic ulcerations may cause perforation or hemorrhage.

Regular use can cause nasal perforation.

The resulting oxygen starvation can cause ulcers, or even perforation of the stomach or intestines.

The tumor can also cause perforation.