Yes, for some people infection with the 'disease' does cause madness.

Albanus did not know that the blade could cause such madness.

The curse extends to foreign men as well, and is believed to cause impotence, madness or other similar harm.

"The rule restricting travel was created to protect resources, not to cause madness and loss of life," he murmured.

Ghosts may also return and take possession of a living person, causing madness or illness.

Isn't it suicidal to deal with something ugly enough to cause madness?

She is said to be a vile and dark creature, and even thinking about her can cause madness.

The idea prevalent during the 19605 that lack of dreaming might cause madness is anticipated by two hundred years in his writing.

Between 1815 and 1835 there was much discussion on mental effects, with the belief that it caused madness.

Some of these layers are believed occasionally to attach themselves to the living, which can cause madness and even death.