It appears that the 5-HT receptors, expressed in cardiac valves are responsible for the valvulopathies reported from the use of fenfluramine and dexfenfluramine.
"People probably used to think the same about cardiac valves and synthetic kidneys."
The most common sites for cysts include the coronary arteries; and abnormalities in cardiac valves, hernias, and diverticuli are all documented.
"Detection of fastidious bacteria in cardiac valves in cases of blood culture negative endocarditis."
And then there are the people who just come in to have their four limbs rotated and balanced, their cardiac valves lubed.
It is the dilation of narrowed cardiac valves (usually mitral, aortic, or pulmonary).
Commissurotomy of cardiac valves is called valvulotomy.
In particular norfenfluramine is a potent agonist of 5-HT receptors, which are plentiful in human cardiac valves.
An echocardiogram - an ultrasound of the heart - would show whether the noise was coming from an abnormal cardiac valve.
Results of replacement of cardiac valves by homologous dura mater valves.