In their isolated form, illudins show selective toxicity for myelocytic leukemia and other carcinoma cells.

For example, TUC338 is strongly upregulated in human hepatocellular carcinoma cells.

This probably does not reflect accurately the clinical situation, where a primary carcinoma cell grows in a highly vascularised epithelium.

"What remains unclear is whether or not all malignant carcinoma cells must undergo an E.M.T. in order to invade and metastasize."

TEF-1 activity is present in human keratinocytes and cervical carcinoma cells, but not in B-lymphocytes (1, 2).

On the other hand, silencing of ASPP2 expression by methylation was observed in several human carcinoma cells.

This was very successful in downregulating the proliferation of renal carcinoma cells in xenografts.

Expression of epiregulin has been reported to be highest in placenta and in a subset of carcinoma cells.

Since the basement membrane is the first obstacle in the way of extravasating carcinoma cells, the functions of perlecan in this process are multiple.

In mice, inhibition of egfl7 in hepatocellular carcinoma cells decrease tumour growth and micro-vessel density.