There are two main ways in which the sensitivity of InsP 3 -induced calcium release might vary.

Calcium-induced calcium release in cardiac muscle and perhaps also in neurons.

However, not all drugs involve calcium release, and, among those that do, the mechanism for manipulating the calcium level can vary from drug to drug.

It stimulates calcium-induced calcium release at lower cytosolic concentrations of Ca.

Parallel fibre terminals and climbing fibres work together in a positive feedback loop for invoking high calcium release.

Such excessive calcium release can be neurotoxic to the affected cell.

They cause an increased calcium release from the sarcoplasmic reticulum of muscle cells which can result in rigidity and eventual cell breakdown.

An impulse from a nerve cell causes calcium release and brings about a single, short muscle contraction called a muscle twitch.

This phenomenon is called calcium-induced calcium release and increases the myoplasmic free Ca concentration causing muscle contraction.