In deep cerebellar nuclei, calcium currents are not uniformly distributed along a dendrite.
Ectatomin was shown to inhibit L-type calcium currents in isolated rat cardiac myocytes.
It has been shown that taicatoxin blocks the calcium currents in heart cells with IC between 10-500 nM.
These alterations are not limited to calcium currents.
They are molecular constituents of the "calcium release activated calcium currents" (ICRAC).
In these cells, HLTx inhibits up to 67% of the calcium currents, acting on multiple subtypes.
Such instability can be attributed to properties of low-threshold calcium currents.
Evidence for low-threshold calcium current was first described in neurons of the inferior olivary nucleus (1981).
All thalamic relay cells experience these specific voltage-dependent calcium currents, and the cat has proven to be a useful model species to study.
Antiepileptic drugs can control absence seizures by inhibiting the T-type calcium channels which prevents low-voltage calcium currents.