The industrial breakthrough led to a huge population explosion.

They also thought that a premature breakthrough would lead to rear forces and artillery troops falling behind, but ultimately agreed to launch a general assault.

Andrei Sakharov's breakthrough in 1950 led to the first thermonuclear experiment.

"What breakthrough led your father to perfect the technology of magnetohydrodynamic engines?"

Those breakthroughs led to the development of classes of drugs that are now common in the treatment of high cholesterol.

"A breakthrough in any one state would lead very rapidly to market reform schools throughout the country," Mr. Andrews said.

This breakthrough led to the development of techniques for organ transplant.

This breakthrough may lead to more effective treatments for human stroke sufferers.

This breakthrough led to negotiations with Island Records for a deal that was never to be finalized.

A breakthrough in this regard may perhaps lead to changes in other areas, however.