The biggest hindrance to success has been the presence of next door neighbors Kerry.

Yet the biggest hindrance to change may be that most training programs focus on changing doctors' behavior, even though it takes two to make a relationship.

If you cop out, I'll be a big hindrance.

High taxes are the single biggest hindrance to doing business in Russia, he said.

The biggest hindrance in promoting the women's game is that they're afraid it won't draw.

I think that the business model of microsoft is a big hindrance toward a more secure environment.

"I don't know many women who want to become donors," he said, adding that scarcity had been the biggest hindrance to such programs.

Scientists say those restrictions have been a big hindrance.

But perhaps the biggest hindrance to change was the economic situation.

Lack of literacy was a big hindrance in convincing the farmers.