The Pirates beat Pitt then at home, 53-51.
One week earlier, Notre Dame had beaten Pitt by a score of 40-6.
Besides the Hurricanes, the Hokies must go to Syracuse (3-2) and beat Pitt (4-1) at home.
West Virginia also beat Pitt, 63-48, in 1965 in what was then the highest-scoring Division I game ever played.
Howard was also clutch in their next game, hitting a free throw with a less than one second remaining to beat Pitt in a dramatic finish.
Notre Dame beat Pitt, 30-20, and Penn State, 21-3.
Duquesne (5-5), which has beaten Pitt only once since the 1981-82 season, scored only 5 points in the first nine minutes of the second half.
If Boston College had beaten Pitt, it would have clinched the top seeding in the conference tournament.
Syracuse, which has outscored its opponents, 228-85, has beaten Pitt in their last three games.
Seton Hall (16-7, 6-5 Big East) has lost two in a row since beating Pitt.