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Degeneration of the basal cell layer with Civatte or colloid body formation.
Histopathologically, there is inflammation at the dermoepidermal junction and degeneration of the basal cell layer.
In HGPIN, the basal cell layer is disrupted but present.
Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor.
Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer.
Discoid lupus erythematosus (DLE) is an uncommon autoimmune disease of the basal cell layer of the skin.
In stage 0, abnormalcells are found in the squamous cell or basal cell layer of the epidermis (topmost layer of the skin).
This study has shown that EGF can be found in the endothelial cells immediately adjacent to basal cell layers of the normal oesophagus, including those forming papillae.
Interestingly, it seems that p63α is the predominant p63 isotope in epithelial basal cell layers, which are the cell type often associated with the anomalies found in patients with EEC syndrome.
Shelley and Arthur had verified the depth by injecting individual itch powder spicules (Mucuna pruriens) and found that maximal sensitivity was found at the basal cell layer or the innermost layer of the epidermis.
Abnormal mitosis may be abnormally located, e.g. occurring in suprabasal cells (cell layers more superficial to the basal cell layer) or of abnormal form, e.g. "tri-radiate mitoses" (a cell splitting into 3 daughter cells rather than only 2)
In normal skin, the rate of production equals the rate of loss; it takes about two weeks for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum.