anti-neutrophil cytoplasmic antibody

Anti-neutrophil cytoplasmic antibody (ANCA)

It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in Wegener's.

Anti-neutrophil cytoplasmic antibodies (ANCAs) are associated with AS, but do not correlate with disease severity.

Instead, the glomeruli are damaged in an undefined manner, perhaps through the activation of neutrophils in response to anti-neutrophil cytoplasmic antibodies (ANCA).

Approximately 80% of patients have perinuclear anti-neutrophil cytoplasmic antibodies, also called P-ANCA; however, this finding is not specific for PSC.

A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA)

Diagnostic markers include eosinophil granulocytes and granulomas in affected tissue and anti-neutrophil cytoplasmic antibodies (ANCA) against neutrophil granulocytes.

Anti-endothelial antibodies are associated with Takayasu's arteritis and anti-neutrophil cytoplasmic antibodies with macroscopic and microscipic polyarteritis nodosa or with Churg-Strauss syndrome.

Determination of Anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and negative ANCAs are not sufficient to reject the diagnosis.

It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes.

Accordingly, we have deliberately not used the terms c-ANCA (anti-neutrophil cytoplasmic antibody exhibiting cytoplasmic pattern) or p-ANCA (anti-neutrophil cytoplasmic antibody exhibiting perinuclear pattern) in describing the antibody.