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Rarely, angioneurotic edema and decreases in hemoglobin, red cells, and platelets have been reported.
Hepatic microsomal enzyme induction, altered lacrimation, menorrhagia, hyperkinesia, hypoesthesia and angioneurotic edema.
Deficiency of this protein is associated with hereditary angioedema ("hereditary angioneurotic edema"), or swelling due to leakage of fluid from blood vessels into connective tissue.
Furthermore the mechanism of focal infection theory survived in general medicine with regards to specific diseases such as tuberculosis, gonorrhea, syphilis, pneumonia, typhoid fever, and mumps as well as conditions such as idiopathic scrotal gangrene and angioneurotic edema.