This finding is further supported by the evidence that adoptive transfer of CD25-depleted splenocytes from arthritic mice does not exacerbate disease in SCID mice.
For example, adoptive transfer is used to study the effects of lymphocytes in the absence of other lymphoid cells.
The body is thus prepared for restoration of immune function by adoptive transfer of new lymphocytes.
Research on adoptive transfer in melanoma patients laid the groundwork for companies focusing on adoptive transfer research in other types of cancer.
The second treatment, adoptive transfer of genetically altered autologous lymphocytes, depends on delivering genes that encode so called T cell receptors (TCRs), into patient's lymphocytes.
Although adoptive transfer of CAR-modified T-cells is a unique and promising cancer therapeutic, there are significant safety concerns.
Combining adoptive transfer and sub-lethal radiation prolongs survival The trials above used defined endpoints (12.6 week and 16 week) to allow comparison of cumulative tumor volume and number.
No reduction in tumor burden was observed following adoptive transfer of non-transgenic splenocytes alone (132% of controls).
If this hypothesis is correct, then adoptive transfer of effector T cells should follow, rather than precede as at present, administration of systemic IL-2 [ 27, 28].
Passive or "adoptive transfer" of cell-mediated immunity, is conferred by the transfer of "sensitized" or activated T-cells from one individual into another.