He added 756 yards and 8 touchdowns running the ball.
He also added 875 yards and 19 touchdowns on offense.
Green Bay added two touchdowns in the last quarter to win the game, 20-6 to take a one-game lead.
Florida added two more touchdowns before the half to widen the gap to 28-3.
Nesbitt added two more touchdowns, the final coming late in 4th quarter.
He also had 993 rushing yards on 189 carries and added eight more touchdowns.
Cleveland added five more touchdowns in the second half and held a comfortable lead to the end.
The Tigers added two more touchdowns in the fourth quarter to go out on a 20-0 run.
He also added three touchdowns for the season and tied a club record with 120 in his Saints career.
He also added two additional touchdowns on interception returns in the post season.