It shares track with the D Line from 18th Street to I-25 & Broadway, then runs along the Southeast Corridor to Lincoln Avenue in Lone Tree.

With the opening of the Southeast Corridor on November 17, 2006, weekend C service was discontinued except for certain sporting events, with the new E line operating seven days per week.

On January 28, 2010, the White House announced that Southeast Corridor would receive $620 Million of its request.

Additionally, light rail service along the Southeast Corridor began in late 2006.

November 17, 2006: The Southeast Corridor, a component of the T-REX transportation project, opened.

The light rail line known as the Southeast Corridor opened shortly after 11 a.m. on November 17, 2006.

The Regional Transportation District in Denver has a flying junction between the Southeast Corridor and the I-225 Corridor.

At this location, the Southeast Corridor is located on the west side of I-25 and the I-225 Corridor is located in the median of I-225.

It is the southernmost station before the Interstate 225 branch splits from the Southeast Corridor and serves as a transfer station for each line.

Facilitating a circumferential link between the Southeast Corridor and the East Corridor is the I-225 Corridor, a new 10.5-mile (16.8-km) light rail line running through Aurora.