Seneca Creek may refer to some water bodies in the United States:

Little Seneca Creek.

At Seneca Rocks, the North Fork is met by Seneca Creek.

Survey maps show that the town's southern boundary runs along Little Seneca Creek.

Just west of where Seneca Creek empties into the Potomac is the Seneca Quarry.

The lake was created by the construction of a dam on Little Seneca Creek.

A dam was constructed across Seneca Creek, which is actually a series of seeps except after heavy rains.

Numerous quarries operated on the one-mile stretch of the Potomac River west of Seneca Creek.

The alga was found in Seneca Creek in Pendleton County in 2009.

Because of the canal, the nearby quarry operations, and additional mills on Seneca Creek, the town of Seneca was an active working class community.