It was originally designed to support SCSI drives.
In the 1980s CDC was left primarily as a hard disk manufacturer, and their series of SCSI drives were particularly successful.
The reason for this is largely to do with SCSI hard drives and the need for double buffering - see info box.
The SS10's enclosure can hold two 50-pin SCSI hard drives and a floppy disk drive.
A SCSI hard drive may also have been added below the front right panel area.
A common AppleShare machine was the Mac Plus with an external SCSI hard drive.
Serial SCSI drives have SCA connectors with a smaller number of pins.
Internally, It has a 3.5" SCSI hard drive.
Most of MMC-3 is supported, which means proper emulation of a SCSI optical drive.
Nearly all SCSI hard drives being manufactured at the end of 2003 were Ultra-320 devices.