They are thought to have died out around 24,000 years ago, at least 2,000 years after the extinction of the last Neanderthal populations elsewhere in Europe.
The area of the city has been populated since prehistory, and the earliest remains belong to Neanderthal populations from the Paleolithic.
This high frequency may suggest some gene flow between ancestral humans and Neanderthal populations.
They have argued that early modern humans all emerged from Africa and wiped out the Neanderthal population in Europe.
While the skull was one of the first to be found, it was also possibly from one of the last surviving Neanderthal populations.
However, not all of them distinguish specific Neanderthal populations from various geographic areas, evolutionary periods, or other extinct humans.
It is estimated that the total Neanderthal population across this habitat range numbered at around 70,000 at its peak.
Rather than absorption of the Neanderthal population, this gene flow appears to have been of limited duration and limited extent.
It is claimed that the practice was also prevalent in some Neanderthal populations.
H. sapiens reached Europe around 43,000 years ago, eventually replacing the Neanderthal population.