With 30 destinations in Mexico, IAH offers service to more Mexican destinations than any other U.S. airports.

America West Airline leased four Boeing 747 aircraft (formerly operated by KLM), offering service to Hawaii and Nagoya, Japan, as well as an expanded service to many Mexican destinations.

Continental (from Houston), Aeroméxico and Mexicana all offer large numbers of Mexican destinations.

On June 1, 2006, ASA filed with the US Department of Transportation for an exemption to begin service from Los Angeles International Airport to nine Mexican destinations under the Delta Connection brand.

The airline flies to 19 Mexican destinations and Los Angeles, but is apparently authorized to fly 50 routes.

In January 2012, Southwest Airlines expressed interest in serving Mexican and South American destinations out of Hobby.

IAH offers service to the most Mexican destinations of any U.S. airport.

For the first forty years of its existence, Continental was a domestic airline; however, especially after the incorporation of Texas International routes, it has served more Mexican destinations than any other U.S. carrier since the mid-1980s.

As of June 2011, the following Mexican domestic destinations are served on a scheduled basis:

As of 2007, with 31 destinations in Mexico, the airport offers service to more Mexican destinations than any other United States airport.