East-west highway New York State Route 18 (Roosevelt Highway) and north-south highway New York State Route 63 (Lyndonville Road) cross in the north part of the town north of Yates Center.

New York State Route 104 (Lewiston Rd., Main St.), signed as an East-West highway, NY 104 has a North-South orientation in the city that roughly parallels Robert Moses State Pkwy.

U.S. Route 20 (Broadway) An East-West highway running through the Village and Town of Lancaster.

Potomac prospered into the late 20th century, with a population peaking at 900 during the 1970 census, due in part to its location along US Route 136, one of the primary East-West highways crossing the state of Illinois.

East-west highways New York State Route 37B intersects New York State Route 37 in the village, and both intersect New York State Route 420, a north-south highway.

East-west highways, New York State Route 29 and New York State Route 67, intersect in the city and also cross the north-south highway New York State Route 30A.

The "backbone" made it very difficult for road building and today, there are only a few routes cutting across the highland namely East-West highway (Kota Bahru - Grik), KL-Kuantan highway and the old Gua Musang road.

From there, take the East-west highway (make it daytime because you won't want to miss the lovely scenery) and North-South highway to transit in Ipoh.

New York State Route 952Q (Walden Ave.) An East-West highway through the Village and Town Lancaster.

The land on the northern area of East-West national highway before the hilly area is traditionally used for farming due to the better irrigation system.