Doug West made a steal and went the length of the court for a slam dunk, tying the score with 3 minutes remaining.
Doug West scored 27 points as the Wolves recorded their 20th victory, one more than they had last season.
The rivalry was perhaps most intense in the 1980s, marked by controversy surrounding the schools' mutual recruitment of Doug West.
Villanova (18-11, 9-7) got 17 points from Doug West before he fouled out with four minutes to play.
Doug West sank a two free throws to put Villanova (7-3) ahead, 64-63, with 33 seconds left.
Doug West scored 23 points to pace the Timberwolves, who fell to 1-13 and lost their seventh straight.
Doug West grabbed 8 rebounds and scored 16 points.
Doug West had 18 points to lead the Wildcats, who fell to 13-11 and 4-6.
Doug West and Jerome Richardson had 8 points each for Minnesota.
Doug West scored 23 points for the Timberwolves.