Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen.

The C-terminal fragment of the cleaved subunit bears an N-terminal arginine, a destabilizing residue in the N-end rule.

The latter antibody has high affinity for C-terminal fragments greater than eight residues and no appreciable affinity for the C-terminal tryptic hexapeptide.

The present study has made use of antibodies that react with progastrin itself, its major active products, Gly-extended biosynthetic intermediates, and its C-terminal tryptic fragment.

The OH is a poorer leaving group than the C-terminal fragment, so, when the tetrahedral intermediate collapses again, S195 leaves and regains a proton from H57.

These regions correspond to the N-terminal fragment of PS-1 but the structure of the C-terminal fragment was disputed.

The structure of the presenilin-1 C-terminal catalytic fragment was determined using solution NMR.

Subbalakshmi C, Nagaraj R, Sitaram N. Biological activities of C-terminal 15-residue synthetic fragment of melittin: design of an analog with improved antibacterial activity.

These modified C-terminal fragments were subcloned into the NdeI and BamHI sites of the His-tagged expression vector, pET15b.

The only tested short C-terminal fragment of IQGAP1 (aa 1503 to 1657) was not activating the mDia1 actin polymerization activity in vitro.