"mouse" nach Englisch mit Beispielen - Kollokationen-Wörterbuch Englisch
- Grotesque manipulations are possible, to be sure: imagine chimeric mice with nascent human brain cells developing within their tiny skulls.
- The general methods for creating chimeric mice can be summarized either by injection or aggregation of embryonic cells from different origins.
- The first chimeric mouse was made by Beatrice Mintz in the 1960s through the aggregation of eight cell stage embryos.
- Since this discovery occurred in 1999, ES cells have become a key tool in the generation of specific chimeric mice.
- Finally, chimeric mice where the modified cells make up the reproductive organs are selected for breeding.
- Unfortunately, two of the four genes used (namely, c-Myc and KLF4) are oncogenic, and 20% of the chimeric mice developed cancer.
- To generate chimeric mice the embryos were allowed to develop to term.
- The result is a chimeric mouse, which develops with a portion of its cells containing the ES cell genome.
- Groα/MGSA and IL-8 have also been shown to enhance re-epithelialization of human skin grafts in chimeric mice [ 29 38 ] .
- Transgenic mice and embryos can be generated from these ES cells by standard injection into blastocysts and subsequent breeding of the resulting chimeric mice.
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