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The exact cause of yellow nail syndrome is not known.
One study indicates a possible connection between titanium and yellow nail syndrome.
Yellow nail syndrome usually affects older adults.
Yellow nail syndrome has been reported to run in families suggesting that genetic factors may play a role in the development of the disorder in these cases.
There is some evidence the rare disease Yellow nail syndrome may be caused by titanium, either implanted for medical reasons or through eating various foods containing titanium dioxide.
To avoid misdiagnosis as nail psoriasis, lichen planus, contact dermatitis, trauma, nail bed tumor or yellow nail syndrome, laboratory confirmation may be necessary.
Restated, yellow nail syndrome is characterized by marked thickening and yellow to yellow-green discoloration of the nails often associated with systemic disease, most commonly lymphedema and compromised respiration.
Congenital lymphedema is frequently syndromic and is associated with Turner syndrome, Lymphedema-distichiasis syndrome, yellow nail syndrome, and Klippel-Trénaunay-Weber syndrome.