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At Karl Ludwig's laboratory in Leipzig he performed important studies on the vasomotor nerves of the tongue.
Currently, new research has been performed suggesting that vasomotor topographic patterns are not consistent with traditional vasomotor nerve topography charts.
In 1840 he made first mention of vasomotor nerves in a treatise titled Physiologisch-pathologische und medicinisch-praktische Untersuchungen über die Spinal-Irritation.
Charles C. Gross writes that Bernard became known, during his early career, for a number of discoveries, including the glycogenic function of the liver, the role of the pancreas in digestion, the regulation of temperature by vasomotor nerves, the action of curare and carbon monoxide, and the vagal control of cardiac function.